Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium.
نویسندگان
چکیده
This retrospective cohort study revealed that linezolid resistance in vancomycin-resistant Enterococcus faecium was dependent on prior linezolid exposure and duration of linezolid therapy. These strains of E. faecium were resistant to the entire class of oxazolidinones.
منابع مشابه
Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: a case report.
OBJECTIVES Linezolid is an oxazolidinone antibiotic used in the treatment of infections caused by vancomycin-resistant enterococci. Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. PATIENT AND METHODS We present clinical details and susceptibility data from multiple Enterococcus faecium strains isolated from a liver transplant patient over 13 mon...
متن کاملEmerging linezolid-resistant, vancomycin resistant Enterococcus faecium from a patient of a haematological unit in Poland.
The oxazolidinone antimicrobial, linezolid, has been approved for the treatment of infections caused by various gram-positive bacteria, including vancomycin-resistant enterococci (VRE). This is the first report on isolation of a linezolid resistant, vancomycin-resistant Enterococcus faecium (LRVREF) strain in Poland, from a Haematological Unit patient in the Clinical Hospital in Gdańsk. PCR-RFL...
متن کاملLinezolid treatment for osteomyelitis due to vancomycin-resistant Enterococcus faecium.
The incidence of nosocomial infections caused by vancomycin-resistant enterococci has risen substantially during the past 15 years. We report the use of linezolid for the successful treatment of hip prosthesis infection associated with osteomyelitis due to vancomycin-resistant Enterococcus faecium.
متن کاملRisk factors for non-vancomycin-resistant enterococcus faecium infection
Results We studied 841 patients, 21 of them (2.5 %) with an E. Faecium infection. No E. faecium vancomycin resistance was found. Patients with E. Faecium isolation were older (69.5 vs 64), infections had been acquired in the hospital, were surgical patients in higher proportion and had longer ICU stay (81 vs 44.3 % p 0.001 and 57.1 vs 27.5 % p 0.003 and 6 (3-11) vs 13 (6-25) p 0.001 respectivel...
متن کاملRapid emergence of resistance to linezolid during linezolid therapy of an Enterococcus faecium infection.
We report the emergence of linezolid resistance (MICs of 16 to 32 mg/liter) in clonally related vancomycin-susceptible and -resistant Enterococcus faecium isolates from an intensive care unit patient after 12 days of linezolid therapy. Only linezolid-susceptible isolates of the same clone were detected at 28 days after termination of linezolid therapy.
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 35 10 شماره
صفحات -
تاریخ انتشار 2002